Dermamelan® and Cosmelan® are professional depigmentation concepts by mesoestetic that target stubborn hyperpigmentation such as melasma, lentigines or post-inflammatory spots. The distinctive approach: instead of merely “covering up” on the surface, both methods address pigment formation at its root and combine an in-clinic phase with consistent home care. A professional session in the practice is followed by a clearly structured home routine lasting several months, which stabilises the result, reduces relapses and supports the skin barrier. For the practice, this means a predictable protocol with a defined patient journey and measurable stages – from the initial mask to the maintenance phase. During the consultation, it is possible to explain transparently what can realistically be expected: a progressively more even complexion with reduced spot intensity, provided that the home application and daily sun protection are adhered to reliably. The systems are designed for various pigmentation concerns and have become established internationally – one reason why many skin centres use them as a standard solution for hyperpigmentation. An individual assessment (medical history, skin type, triggers, photoprotection) and clear information about behavioural guidelines such as avoiding UV exposure remain important. Integrated in this way, Dermamelan® and Cosmelan® are effective building blocks for addressing visible pigmentation irregularities in a lasting way – with a structured, practice-proven process that patients can easily understand.